Pros and Cons of Guarana

Guarana pros and cons

If you enjoyed an energy drink recently, chances are it contained an ingredient known as guarana (Paullinia cupana). This plant, which is native to the Amazon rainforest, is the source of a substance associated with several health benefits, along with some cautionary notes. 

What is guarana?

Guarana is a Brazilian plant that is highly regarded by natives for its healing qualities. The mature fruit of this climbing vine is bright red and the size of a coffee berry. The black seed in the berries is a significant source of the stimulants caffeine, theobromine, and theophylline, as well as the antioxidants catechins, saponins, and tannins.  

Health benefits of guarana

Kills bacteria. It’s been suggested that caffeine, along with tannins or catechins found in guarana, are the source of its antibacterial properties. However, what has been shown is that guarana can kill Escherichia coli and Streptococcus mutans, bacteria that can cause diarrhea and tooth decay, respectively.  

High in antioxidants. The various antioxidants found in guarana can help fight cell and tissue damage related to free radical activity. 

NATURALLY SAVVY NEWSLETTER
Get the latest information, tips & recipes for healthy living delivered directly to your inbox.
Your privacy is important to us.

Boosts mental energy and focus. The high caffeine content of guarana (the seeds contain up to six times more caffeine than coffee beans) can help increase mental energy, reduce fatigue, and improve focus. A study that compared the use of vitamins with guarana and a placebo group found that those who consumed the guarana had less fatigue. 

Read about 8 ways to fight fatigue and boost energy

Improves memory and learning ability. Research has indicated that low doses of guarana (i.e., 37.5 or 75 mg) improved learning ability and did so better than higher doses. The authors suggested that this shows that compounds other than caffeine are providing this benefit. In a study that compared the brain-enhancing compound ginseng with guarana, the use of the latter resulted in faster testing times and better concentration.

May aid weight loss. The high caffeine content in guarana may accelerate metabolism by as much as 11 percent during a 12-hour period and thus aid weight loss. Guarana’s impact on fat cell production, however, is not clear.

Enhance heart health. You’ve probably heard of bad cholesterol (aka, low-density lipoprotein LDL), and guarana may reduce oxidation of this harmful substance, according to research. The antioxidants in guarana also may improve blood circulation.

Skin health. Some cosmetics contain guarana, as the antioxidants may reduce skin damage associated with age, minimize wrinkles around the eyes, and reduce sagging skin in your cheeks.

Help digestive problems. Do you experience constipation or diarrhea? The tannins in guarana may help with diarrhea since they are astringent. Low doses of guarana can have an anti-diarrheal effect. High doses (and thus more caffeine) may help with constipation.

Read about caffeine: healthy or health risk?

Cons of guarana

When consumed in amounts typically found in foods or in the short-term for medicinal purposes, guarana is usually safe for most adults. In a 2019 review, the authors noted that “guarana is not currently known to be associated causally with any serious health risks when consumed properly” and that “if guidelines for caffeine intake are respected,” using guarana is “not likely” to cause harm.

However, high doses (more than 400 mg of caffeine daily), long-term use, or use by individuals who have certain health challenges may cause mild to severe side effects. These can include stomach irritation, nervousness, vomiting, and insomnia. Individuals who have specific conditions such as bladder control problems, diabetes, bleeding disorders, heart disease, high blood pressure, glaucoma, irritable bowel syndrome, or seizures may experience reactions associated with their health issues. 

Bottom line

Guarana is a natural remedy that may provide significant health benefits when used wisely. You can find guarana in energy drinks and as a supplement (pills, capsules, powder), but in all cases, be aware of the caffeine content. 

Sources
Bittencourt LS et al. The protective effects of guaraná extract (Paullinia cupana) on fibroblast NIH-3T3 cells exposed to sodium nitroprusside. Food and Chemical Toxicology 2013 Mar; 53:119-25
Dulloo AG et al. Normal caffeine consumption: influence on thermogenesis and daily energy expenditure in lean and postobese human volunteers. American Journal of Clinical Nutrition 1989 Jan; 49(1):44-50. 
da Fonseca CA et al. Genotoxic and mutagenic effects of guarana (Paullinia cupana) in prokaryotic organisms. Mutation Research 1994 May; 321(3):165-73.
Haskell CF et al. A double-blind, placebo-controlled, multi-dose evaluation of the acute behavioural effects of guaraná in humans. Journal of Psychopharmacology 2007 Jan; 21(1):65-70.
de Jesus NZ et al. Tannins, peptic ulcers and related mechanisms. International Journal of Molecular Science 2012; 13(3):3203-28.
Kennedy DO et al. Improved cognitive performance and mental fatigue following a multi-vitamin and mineral supplement with added guaraná (Paullinia cupana). Appetite 2008 Mar-May; 50(2-3):506-13.
Kennedy DO et al. Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract: comparison and interaction with Panax ginseng. Pharmacology Biochemistry and Behavior 2004 Nov; 79(3):401-11
de Lima Portella R et al. Guaraná (Paullinia cupana Kunth) effects on LDL oxidation in elderly people: an in vitro and in vivo study. Lipids in Health and Disease 2013 Feb 8
Lohsiriwat S et al.Effects of caffeine on anorectal manometric findings. Diseases of the Colon and Rectum 2008 Jun; 51(6):928-31.
Peixoto H et al. Anti-aging and antioxidant potential of Paullinia cupana var. sorbilis: Findings in Caenorhabditis elegans indicate a new utilization for roasted seeds of guarana. Medicines (Basel) 2017 Aug 15; 4(3):6
Peirano RI et al. Dermal penetration of creatine from a face-care formulation containing creatine, guarana and glycerol is linked to effective antiwrinkle and antisagging efficacy in male subjects. Journal of Cosmetic Dermatology 2011 Dec; 10(4):273-81. 
Raman R. 12 benefits of guarana (plus side effects). Healthline 2018 13 Jun
Smolarek PC et al. In vitro antimicrobial evaluation of toothpastes with natural compounds. European Journal of Dentistry 2015 Oct-Dec; 9(4):580-86.
Subbiah MT, Yunker R. Studies on the nature of anti-platelet aggregatory factors in the seeds of the Amazonian Herb Guarana (Paullinia cupana). International Journal of Vitamin and Nutrition Research 2008 Mar; 78(2):96-101.
WebMD. Guarana: uses, side effects, and more. 
Leave a Comment

Deborah is a freelance health writer who is passionate about animals and the environment. She has authored, co-authored, and written more than 50 books and thousands of articles on a wide range of topics. Currently, she lives in Tucson, Arizona.